interaction of electromagnetic field and modulation of gaba-b receptor on serum testosterone concentration in aggressive rats

introduction: the aim of the present study is to investigate the effect of interaperitoneal injection of baclofen (gaba-b agonist) and cgp35348 (gaba-b antagonist) on serum testosterone concentration in aggressive rats exposed to electromagnetic field. methods: fifty five mature male rats weighing 200±20 grams were studied. animals were divided into 2 main groups and four subgroups. main groups composed of rats with and without exposure to electromagnetic field. animals in the former group were exposed to electromagnetic field with 500 t intensity and 50hz frequency for 8 hours a day for 30 days. aggression was induced by applying 2ma current every 3 seconds for 5 minutes. then serum testosterone concentration was measured by radioimmunoassay method. results: data showed that baclofen injection at 3mg/kg and cgp35348 at 100mg/kg significantly increased serum testosterone concentration in aggressive rats exposed to electromagnetic field. conclusion: according to the simillar effect of baclofen and cgp35348 on testosterone secretion, it seems that gaba-b receptors in testes are two types, so it has caused similar effects. also, electromagnetic exposure leads to increase in testosterone secretion.